Lipid metabolism in man

Thematic review series: Lipid droplet synthesis and metabolism: from yeast to man. Lipid droplet-based storage fat metabolism in Drosophila.

The fruit fly Drosophila melanogaster is an emerging model system in lipid metabolism research. Lipid droplets are omnipresent and dynamically regulated organelles found in various cell types throughout the complex life cycle of this insect. The vital importance of lipid droplets as energy resources and storage compartments for lipoanabolic components has recently attracted research attention t...

Cholesterol metabolism in man.

It has been previously demonstrated that, in the rat, the major metabolic pathway of cholesterol involves the conversion of this molecule to bile acids (1, 2). These are excreted into bile and after repeated enterohepatic circulation (3) are finally eliminated in the feces, still in the form of bile acids. Over 80 per cent of the body's cholesterol was found to be metabolized in this manner (1,...

Pyrimidine metabolism in man.

Tryptophan Metabolism in Man.

The amino acid tryptophan is unique because it contains the indole nucleus and because it is metabolized in man through several different biochemical pathways to a number of specific products. It is the precursor of serotonin and 5-hydroxyindoleacetic acid. In addition, after cleavage of the indole ring, it may be metabolized by way of the kynurenine pathway to 3-hydroxyanthranilic acid and ult...

A quantitative metabolic defect in lipid metabolism associated with abnormal serum lipoproteins in man.

Tritium-labeled cholesterol has been fed to a selected series of patients to demonstrate a quantitative metabolic defect in lipid metabolism in the presence of abnormal serum lipoprotein spectra. Patients with abnormal serum lipoprotein spectra carry a greater fraction of their newly absorbed cholesterol in the esterified form than do normals. THE LIPOPROTEINS of human serum are conveniently de...